The consortium project, funded by the German Federal Ministry of Education and Research under the code 13GW0365B, achieved the first clinical use of magnetic resonance imaging (MRI) for thrombectomy, a milestone that required the development of a fully MRI‑compatible thrombectomy system. EP FLEX Feinwerktechnik GmbH, the German company that had already pioneered the world’s smallest MRI‑visible thrombectomy basket, led the research and development of the key hardware components. The project’s primary technical deliverables were a 0.4 mm diameter MRI‑visible thrombectomy basket, a 0.2 mm diameter MRI‑compatible guidewire, and a novel MRI‑visible snare loop that could be visualised and manoeuvred under real‑time MRI guidance. The basket, constructed from a Nitinol‑stainless steel composite bonded by a proprietary 6‑year‑developed technique, retained its mechanical integrity while remaining fully visible on MRI sequences. The guidewire incorporated a Kevlar fibre core coated with a Peek polymer, a design that preserved MRI safety and provided the necessary flexibility for navigation through tortuous vascular pathways. The guidewire system achieved CE‑mark approval, confirming its compliance with European safety and performance standards. Electrical resonant markers, fabricated as miniature coils integrated into the basket and snare loop, served as active RFID tags that enhanced localisation on MRI and provided real‑time feedback during the procedure. In the second work package, the snare loop was characterised through a series of MRI and operative tests conducted at the Institute of Clinical and Experimental Radiology (ICCAS). These tests demonstrated that the loop could be accurately visualised at clinically relevant field strengths and that it could be deployed and retrieved with the same precision as conventional mechanical snares, but without the need for fluoroscopic guidance. The project also refined the bonding process between Nitinol and stainless steel, a critical step that allowed the creation of hybrid devices that combine the shape‑memory properties of Nitinol with the robustness of stainless steel. The consortium’s collaborative framework divided responsibilities clearly: EP FLEX handled the design, fabrication, and bench‑testing of the basket, snare loop, and guidewire; ICCAS performed the MRI safety and efficacy studies, as well as the operative validation in animal models. The project’s timeline, spanning from the initial design phase through to the final validation, was coordinated through a series of milestone reviews that ensured alignment with regulatory requirements and clinical translation goals. By integrating advanced materials science, electromagnetic engineering, and clinical imaging, the consortium produced a suite of MRI‑compatible thrombectomy tools that set the stage for safer, more precise vascular interventions and opened new avenues for MRI‑guided endovascular therapy.
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