Rather than reshuffling and grafting existing enzymes in line with current metabolic-engineering thinking, FutureAgriculture’s approach demands the de novo engineering of new enzymes in order to catalyse metabolic transformations that are still unknown in nature. Computational power and chemical logic have helped the identification of the most promising synthetic pathways: short pathways that convert 2-phosphoglycolate (2-PG) into an intermediate compound of the Calvin cycle without releasing CO2. The pathways include both known reactions that are catalysed by existing enzymes as well as plausible reactions by engineered enzymes. The routes have been tested in vitro, then in engineered bacteria that support the evolution of the pathway activity, and later in a simple photosynthetic organism, the cyanobacteria, following by testing in model plant system. Plant growth rate and biomass yield are expected to increase under various environmental conditions, thus, paving the way for enhanced agricultural productivity of crops like rice, wheat, barley, oat, soybean, cotton, and potato.