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Advancing cell secretome-based therapies

This call supports innovative research on the therapeutic use of cell secretomes — the collection of factors secreted by cells, including extracellular vesicles (EVs), proteins, lipids, and nucleic acids. It aims to develop safe, effective, and scalable secretome-based therapies as an alternative or complement to cell transplantation therapies.

The opportunity is designed for projects that move beyond the exploratory phase, aiming to generate robust preclinical data and lay the groundwork for clinical translation. The objective is to enable the development of therapeutic products derived from cell secretions with well-characterized modes of action, manufacturing processes, and safety profiles.

Opening: 22 May 2025
Deadline(s): 18 Sep 2025

Expected Outcome

  • Delivery of clinically relevant secretome-based therapeutic candidates.

  • Robust data on efficacy, safety, and mechanism of action.

  • Standardized and reproducible production pipelines.

  • Evidence to support regulatory acceptance and clinical testing.

  • Insights into therapeutic advantages compared to cell-based approaches (e.g., reduced immunogenicity, logistical simplicity).

Scope

Projects should focus on:

  • Characterizing therapeutic secretomes, especially extracellular vesicles (e.g., exosomes), and their functional components.

  • Developing and validating scalable production and purification methods that are GMP-compliant.

  • Investigating biodistribution, targeting, stability, and efficacy in relevant in vitro and in vivo models.

  • Establishing mechanisms of action and safety profiles through rigorous analytical frameworks.

  • Addressing regulatory and standardization challenges for clinical implementation.

Research must be translational in nature, ideally involving cross-sectoral consortia including academic researchers, SMEs, biotech firms, and clinical experts.

Partner Requests

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