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Cost-effective and robust continuous biotech bio-based processes

This Horizon Europe Innovation Action (IA) call aims to develop cost-effective and robust continuous biotech bio-based processes to improve sustainability and competitiveness in industrial biotechnology. The focus is on transitioning from batch or fed-batch processes to continuous biotech processes for bio-based chemicals, materials, and ingredients.

Key objectives include:
- Enhancing process efficiency, reducing equipment downtime, and lowering operational costs.
- Addressing contamination risks, genetic stability of cells, and improving monitoring and control systems.
- Demonstrating continuous biotech processes for microbial, cell factory, or enzymatic production.
- Implementing efficient downstream processing (DSP) systems to achieve high purity.
- Integrating AI and digital tools for monitoring and control.
- Applying the Safe-and-Sustainable-by-Design (SSbD) framework for environmental sustainability.

The results of the projects funded under this call will contribute to EU initiatives such as the Bioeconomy Strategy, Circular Economy Action Plan, EU Zero Pollution Ambition, and the EU Industrial Strategy.

Opening: 04-04-2025
Deadline(s): 17-09-2025

Expected Outcome

• Increased scale-up potential and sustainability of biotech processes.
• Enhanced adaptability and integration with existing industrial infrastructures.
• Increased and stable productivity compared to benchmark batch processes.
• Improved product purity meeting industry requirements.
• Lower operational expenditures, boosting industrial competitiveness.
• Development of innovative production technologies in the bio-based industry.
• Reinforced integration of bio-based research with industrial applications.
• Contribution to EU sustainability, circularity, and climate neutrality goals.

Scope

• Identify bottlenecks in transitioning to continuous biotech processes.
• Demonstrate continuous biotech processes for sustainable bio-based chemicals, materials, and ingredients.
• Develop efficient downstream processing systems ensuring high product purity.
• Address resource and energy efficiency through process intensification.
• Implement AI-driven monitoring and control systems.
• Apply Safe-and-Sustainable-by-Design (SSbD) framework.
• Valorise upstream and downstream side-streams to improve circularity.
• Ensure synergy with past and ongoing EU-funded projects.