A new product was developed as potential multi-mycotoxin adsorbent. This product was evaluated in vitro at different pH values simulating those encountered in the GI tract of animals. Then, the efficacy of the additive in adsorbing mycotoxins was confirmed in vivo in short-term toxicokinetic studies with rats and piglets. Mycotoxins, with or without the detoxifier, were administered by a single oral intragastric bolus and their metabolites were determined in urine of rats and plasma of piglets. The reduction of mycotoxins and metabolites in urine and plasma confirmed that a reduction of mycotoxins systemic exposure occurred in presence of the additive.