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CryoTEM

Listing Description

Cryo-electron microscopy (Cryo-EM) is employed to preserve and scrutinize the micro and nanostructures of liquids, along with their interactions with substrates. This technique proves especially beneficial for investigating processes like emulsion, dispersion, and gel-based aqueous chemical products, as well as biological samples, all under low-temperature conditions facilitated by cryopreservation.</p>

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Applications:
Cryo-EM analysis is especially well-suited for examining membrane proteins, protein complexes, and large macromolecular assemblies like viruses, ribosomes, and proteasomes. Through single particle analysis, it offers insights into the molecular intricacies that govern interactions among proteins, small molecules, and post-translational modifications within expansive and dynamic protein systems under near-native conditions. Such insights illuminate the mechanisms through which intricate biological systems impact human health and disease.

Value Proposition:

Accurate three-dimensional (3D) structural information is pivotal for the discovery and refinement of drug candidates, as well as for elucidating mechanisms of action. As a premier service provider in electron microscopy, INL facility leverages a cutting-edge technology platform encompassing several techniques and equipment useful for industry and academia. We offer a holistic solution for target structure determination with state-of-the-art biophysical techniques, leading the biological discovery and optimization supporting formulated chemical product innovation.

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Adress:

R. Dr. Carlos Lloyd Braga 49
Braga
Braga
4715-319
Portugal

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