Result description
Problem:
(1) Many medical implants have to be removed after some months or years
(2) Implants are over-grown by tissue within weeks/months making explantation harmful
(3) Measures hindering overgrowth can activate blood clotting / immune system or cause infections
Alternative Solutions:
(1) Make explantation early or never
(2) Coatings (disadvantages: durability, approvals, side effects, need for medicaments)
Our Solution:
(1) Femtosecond-laser induced cell-repellent micro- and nano-structures
(2) Oxide layer at surface obtained by anodization optimized for low cell attachment
Advantage of Our Solution:
(1) Cell-repellent surface
(2) Topographic and chemical surface modification of implant itself (no coating)
(3) Surface remains hemo-compatible and bio-compatible
(4) Effect can be restricted to limited area at implant surface
Customer Segments:
(1) Producers of cardio-vascular devises: pace makers, miniaturized pacemakers, defibrillators, stents, artificial hearts, etc.
(2) Producers of other implants: bone, joint replacement, dentistry, insulin pumps, etc.
(3) Producers of cell-chips for replacement of animal tests
Addressing target audiences and expressing needs
- Grants and Subsidies
- Business partners – SMEs, Entrepreneurs, Large Corporations
Partners are searched for further research & development activities.
Several possibilities:
(1) Contract research for partners from industry
(2) European or national funded project with industrial partner: possible submission autumn 2019, duration 24 to 48 months
(3) University start-up, funded or with venture risk capital, resources for up to 3 year, thereof at least 1 year incubation an the university before founding, then first contract work
- Public or private funding institutions
- Other Actors who can help us fulfil our market potential
- Private Investors
R&D, Technology and Innovation aspects
Preliminary Results Achieved:
(1) Casings of pacemakers can be laser-treated and anodized
(2) Cell-repellence (fibroblasts) obtained for cylinders standing in Petri dishes with cells (in-vitro proof of principle)
(3) For osteoblasts laser-induced microstructures + anodization result in improved cell growth => new opportunities
Result submitted to Horizon Results Platform by BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG
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